The ‘LOCO’ project, the Low Countries: Crossroads of Europe from the Neolithic to the Late Middle Ages, is a large-scale project with strengths in applying a diachronic and transdisciplinary approach, combining history and archaeological science to explore the mobility of people, materials, and ideas. The LOCO project responds to the need for deep history, pinpointing the drivers of long-run trends in human history. A call to arms for an interdisciplinary revolution in historical research was issued in Nature in 2008, which stated the need to develop unifying theories and test them with data generated by history, archaeology, and other specialized disciplines. The LOCO project addresses this paradigm shift called for in our approach to the human past. To carry out this project, we have assembled a unique team of experts from three different universities: the VUB, the UGent, and the KU Leuven. Merging the mobility data generated in large diachronic studies, drawing from existing databases and the production of new data relating to human and commodity provenance, as well as tracing the circulation of innovations and ideas via an applied digital humanities approach.